Is it real or science fiction to dream of being able to treat… getting old? In this episode, we discuss with Dr. Thomas Rando from Stanford (who directs the Glenn Center for the Biology of Aging), Kristen Fortney, CEO of BioAge, and a16z’s general partner Vijay Pande where we are in the field of “geroscience” — the idea of studying aging itself, and aging as the root risk for all aging related disease. Far from science fiction, recent discoveries have given us a whole crop of promising breakthroughs to treat aging, such as parabiosis (young blood infused into old blood), senolytics, and rapamycin, and more.

Rando Cell Reports podcast

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How sleeping muscle stem cells might be awakened to fight aging, with Thomas Rando  (9:42)  (Cell Reports).

Plus, sample a selection of the hottest new papers from Cell Press (19:30).

 

 

 

Scientists discern signatures of old versus young stem cells

BY BRUCE GOLDMAN

A chemical code scrawled on histones — the protein husks that coat DNA in every animal or plant cell — determines which genes in that cell are turned on and which are turned off. Now, Stanford University School of Medicine researchers have taken a new step in the deciphering of that histone code.

In a study published June 27 in Cell Reports, a team led by Thomas Rando, MD, PhD, professor of neurology and neurological sciences and chief of the Veterans Affairs Palo Alto Health Care System’s neurology service, has identified characteristic differences in “histone signatures” between stem cells from the muscles of young mice and old mice. The team also distinguished histone-signature differences between quiescent and active stem cells in the muscles of young mice.

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Rando Video: Telethon’s Scientific Committee: The Focus on Patient’s Needs

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Fondazione Telethon invests in research in Italy to find cures for rare genetic diseases. Dr. Rando has been a member of the Telethon Scientific Committee since 2009.

The 30 members of the Telethon Scientific Committee met on June 20-21 to give their final assessment of 160 projects that have passed all previous stages of the 2013 selection process.