SELECTED PUBLICATIONS

van Velthoven CTJ, Rando TA (2019) Stem cell quiescence: Dynamism, restraint, and cellular idling. Cell Stem Cell, 24: 213-225.

Liu L, Charville GW, Cheung TH, Yoo B, Santos PJ, Schroeder M, Rando TA (2018) Impaired notch signaling leads to a decrease in p53 activity and mitotic catastrophe in aged muscle stem cells. Cell Stem Cell, 23: 544-556.

Wosczyna MN, Rando TA (2018) A muscle stem cell support group: Coordinated cellular responses in muscle regeneration. Devel Cell, 46: 135-143.

Filareto A, Nguyen KM, Gan Q, Aldanondo G, Machado L, Chamberlain JS, Rando TA (2018) Monitoring disease activity non-invasively in the mdx model of Duchenne muscular dystrophy. Proc Natl Acad Sci, USA, 115: 7741-7746.

Leeman DS, Hebestreit K, Ruetz T, Webb AE, McKay A, Pollina EA, Dulken BW, Zhao X, Yeo R, Ho TT, Mahmoudi S, Devarajan K, Passegué E, Rando TA, Frydman J, Brunet A (2018) Modulating the lysosome impacts protein aggregation in quiescent neural stem cells and ameliorates their ability to activate during aging. Science, 359: 1277-1283.

Rando TA, Ambrosio F (2018) Regenerative rehabilitation: Applied biophysics meets stem cell therapeutics. Cell Stem Cell, 22: 306-309.

Judson RN, Quarta M, Oudhoff MJ, Soliman H, Yi L, Chang CK, Loi G, Vander Werff R, Cait A, Hamer M, Blonigan J, Paine P, Doan LTN, Groppa E, He W, Su L, Zhang RH, Xu P, Eisner C, Low M, Barta I, Lewis CB, Zaph C, Karimi MM, Rando TA, Rossi FM (2018) Inhibition of methyltransferase Setd7 allows the in vitro expansion of myogenic stem cells with improved therapeutic potential. Cell Stem Cell, 22:177-190.

Haller S, Kapuria S, Riley RR, O’Leary MN, Schreiber KH, Andersen JK, Melov S, Que J, Rando TA, Rock J, Kennedy BK, Rodgers JT, Jasper H (2017) Age-related somatic stem cell loss is a consequence of transient mTORC1 activation during regeneration episodes. Cell Stem Cell, 21: 806-818.

van Velthoven CTJ, de Morree A, Egner IM, Brett JO, Rando TA (2017) Transcriptional profiling of quiescent muscle stem cells in vivo. Cell Rep, 21: 1994-2004.

Tang H, Kennedy CL, Lee M, Gao Y, Xia H, Olguin F, Fraga DA, Ayers K, Choi S, Kim M, Tehrani A, Sowb YA, Rando TA, Shrager JB (2017) Smad3 initiates oxidative stress and proteolysis that underlies diaphragm dysfunction during mechanical ventilation. Sci Rep, 7: 14530.

de Morrée A, van Velthoven CTJ, Gan Q, Salvi JS, Klein JDD,  Quarta M, Biressi S, Rando TA (2017) Staufen1 inhibits MyoD translation to actively maintain muscle stem cell quiescence. Proc Natl Acad Sci, USA, 114: E8966-E9005.

Quarta M, Cromie M, Chacon R, Blonigan J, Garcia V, Akimenko I, Hamer M, Paine P, Stok M, Shrager JB, Rando TA (2017) Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss. Nature Commun, 8: 15613.

Stearns‐Reider K, D’Amore A, Beezhold K, Rothrauff BB, Cavalli L, Wagner WR, Vorp D, Tsamis A, Shinde S, Zhang C, Barchowsky A, Rando TA, Tuan RS, Ambrosio F (2017) Aging of the skeletal muscle extracellular matrix drives a stem cell fibrogenic conversion. Aging Cell, 16: 518-528.

Rodgers JT, Schroeder MD, Ma C,  Rando TA (2017) HGFA Is an injury-regulated systemic factor that induces the transition of stem cells into GAlert. Cell Reports, 19: 479-486.

Luo D, de Morree A, Boutet SC, Quach NL, Natu V, Rustagi A, Rando TA (2017) Deltex2 represses MyoD expression and inhibits myogenic differentiation by acting as a negative regulator of Jmjd1c. Proc Natl Acad Sci, USA, 114: E3071-3080..

Brunet A, Rando TA (2017) Interaction between epigenetics and metabolism in aging stem cells. Curr Opin Cell Biol, 45: 1-7.

Mueller AA, van Velthoven CT, Fukumoto K, Cheung TH,  Rando TA (2016) Intronic polyadenylation of PDGFRα in resident stem cells attenuates muscle fibrosis. Nature, 540: 276-279.

Quarta M, Brett JO, DiMarco R, de Morree A, Boutet SC, Chacon R, Gibbons M, Garcia VA, Su J, Heilshorn S, Rando, TA (2016) An artificial niche preserves the quiescence of muscle stem cells and enhances their therapeutic potential. Nature Biotech, 34: 752-759.

Goodell MA, Rando TA (2015) Stem cells and healthy aging. Science, 350: 1199-1204.

Bursac N, Juhas M, Rando TA (2015) Synergizing engineering and biology for treatment and modeling skeletal muscle injury and disease. Ann Rev Biomed Engin, 17: 217-242.

Liu L, Cheung TH, Charville GW, Rando TA (2015) Isolation of skeletal muscle stem cells by fluorescence activated cell sorting. Nat Prot, 10: 1612-1624.

Tang A, Rando TA (2014) Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation. EMBO J, 33: 2782-2797.

Brett JO, Rando TA. (2014)  Alive and well? Exploring disease by studying lifespan. Curr Opin Genet Dev, 26: 33-40.

Rodgers JT, King KY, Brett JO, Cromie MJ, Charville GW, Maguire KK, Brunson C, Mastey N, Liu L, Tsai C-R, Goodell MA, Rando TA (2014) mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert. Nature, 510: 393-396.

Liu L, Cheung TH, Charville GW, Hurgo BMC, Leavitt T, Shih J, Brunet A, Rando TA (2013) Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging. Cell Reports, 4: 189-204

Cheung TH, Rando TA (2013) Molecular regulation of stem cell quiescence. Nat Rev Mol Cell Biol, 14: 329-340.

Maguire KK, Lim LE, Speedy S, Rando TA (2013) Assessment of disease progression in muscular dystrophies by non-invasive imaging. J Clin Invest, 123: 2298-2305.

Mueller AA, Cheung TH, Rando TA (2013) All’s well that ends well: Alternative polyadenylation and its implications for stem cell biology. Curr Opin Cell Biol, 25: 222-232.

Boutet SC, Cheung TH, Quach NL, Liu L, Prescott SL, Edalati A, Iori K, Rando TA (2012) Alternative polyadenylation mediates microRNA regulation of muscle stem cell function. Cell Stem Cell, 10: 327-336.

Cheung TH, Quach NL, Charville GW, Liu L, Park L, Edalati A, Yoo B, Hoang P, Rando TA (2012) Maintenance of muscle stem cell quiescence by microRNA-489. Nature, 482: 524-528.

Rando TA, Chang HY (2012) Aging, rejuvenation, and epigenetic reprogramming: Resetting the aging clock. Cell, 148: 46-57.