Publications

(Selected)

Goodell MA, Rando TA (2015) Stem cells and healthy aging. Science, 350: 1199-1204.

Charville GW, Cheung TH, Yoo B, Santos PJ, Lee GK, Shrager JB, Rando TA (2015) Ex Vivo Expansion and In Vivo Self-Renewal of Human Muscle Stem Cells. Stem Cell Reports, 5: 621-632.

Liu L, Cheung TH, Charville GW, Rando TA (2015) Isolation of skeletal muscle stem cells by fluorescence-activated cell sorting. Nat Protoc, 10: 1612-1624.

Bursac N, Juhas M, Rando TA (2015) Synergizing Engineering and Biology to Treat and Model Skeletal Muscle Injury and Disease. Annu Rev Biomed Eng, 17: 217-242.

Biressi S, Miyabara EH, Gopinath SD, Carlig PM, Rando TA (2014) A Wnt-TGFβ2 axis induces a fibrogenic program in muscle stem cells from dystrophic mice. Sci Transl Med, 6: 267.

Tang AH, Rando TA (2014) Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation. EMBO J, 33: 2782-2797.

Dimmeler S, Ding S, Rando TA, Trounson A (2014) Translational strategies and challenges in regenerative medicine. Nat Med, 20: 814-821.

Benayoun BA, Pollina EA, Ucar D, Mahmoudi S, Karra K, Wong ED, Devarajan K, Daugherty AC, Kundaje AB, Mancini E, Hitz BC, Gupta R, Rando TA, Baker JC, Snyder MP, Cherry JM, Brunet A (2014) H3K4me3 breadth is linked to cell identity and transcriptional consistency. Cell, 158: 673-688. Erratum in: Cell, 163: 1281-1286.

Rodgers JT, King KY, Brett JO, Cromie MJ, Charville GW, Maguire KK, Brunson C, Mastey N, Liu L, Tsai CR, Goodell MA, Rando TA (2014) mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert). Nature, 510: 393-396.

Rando TA, Wyss-Coray T (2014) Stem cells as vehicles for youthful regeneration of aged tissues. J Gerontol A Biol Sci Med Sci, 1: S39-42.

Brett JO, Rando TA. Alive and well? Exploring disease by studying lifespan. (2014) Curr Opin Genet Dev, 26: 33-40.

Gopinath SD, Webb AE, Brunet A, Rando TA (2014) FOXO3 promotes quiescence in adult muscle stem cells during the process of self-renewal. Stem Cell Reports, 2: 414-426.

Liu L, Cheung TH, Charville GW, Hurgo BM, Leavitt T, Shih J, Brunet A, Rando TA (2013) Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging. Cell Rep, 4: 189-204

Mueller AA, Cheung TH, Rando TA (2013) All’s well that ends well: Alternate polyadenylation and its implications for stem cell biology. Curr Opin Cell Biol, 25: 222-232.

Conboy MJ, Conboy IM, Rando TA (2013) Heterochronic parabiosis: Historical perspective and methodological considerations for studies of aging and longevity. Aging Cell, 12: 525-530.

Heredia JE, Mukundan L, Chen F, Mueller AA, Deo R, Locksley RM, Rando TA, Chawla A (2013) Type 2 innate immunity stimulates proliferation of fibro/adipogenic progenitors to facilitate muscle regeneration. Cell, 153: 376-388.

Maguire KK, Lim LE, Speedy S, Rando TA (2013) Assessment of disease progression in muscular dystrophies by non-invasive imaging. J Clin Invest, 123: 2298-2305.

Biressi S, Bjornson CRR, Carlig PMM, Keller C, Rando TA (2013) Myf5 expression during fetal myogenesis defines the developmental progenitors of adult satellite cells. Dev Biol, 379: 195-207.

Cheung TH, Rando TA (2013) Molecular regulation of stem cell quiescence. Nat Rev Mol Cell Biol,14: 329-340.

Charville GW, Rando TA (2013) The “Mortal Strand Hypothesis”: Non-random chromosome inheritance and the biased segregation of damaged DNA. Semin Cell Devel Biol,(Epub ahead of print)

Urciuolo A, Quarta M, Morbidoni V, Gattazzo F, Molon S, Grumati P, Montemurro F, Tedesco F, Cossu G, Vozzi G, *Rando TA, *Bonaldo P (2013) Collagen VI regulates satellite cell self-renewal and muscle regeneration. Nature Commun, 4: 1964. * co-corresponding authors

Rando TA (2012) Recent advances in the pathogenesis and treatment of neuromuscular diseases. Curr Opin Neurol, 25: 586-587.

Barzilai N, Guarente L, Kirkwood TBL, Partridge L, Rando TA, Slagboom PE (2012) The place of genetics in ageing research. Nat Rev Genet, 13: 589-594.

Conboy IM, Rando TA (2012) Heterochronic parabiosis in the study of stem cell aging. Cell Cycle, 11: 2260-2267.

Brack AS, Rando TA (2012) Tissue-specific stem cells: lessons from the skeletal muscle satellite cell. Cell Stem Cell, 10: 504-514.

Boutet SC, Cheung TH, Quach NL, Liu L, Prescott SL, Edalati A, Iori K, Rando TA (2012) Alternative polyadenylation mediates microRNA regulation of muscle stem cell function. Cell Stem Cell, 10: 327-336.

Cheung TH, Quach NL, Charville GW, Liu L, Park L, Edalati A, Yoo B, Hoang P, Rando TA (2012) Maintenance of muscle stem-cell quiescence by microRNA-489. Nature, 482: 524-528.

Rando TA, Chang HY (2012) Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock. Cell, 148: 46-57.

Bjornson CR, Cheung TH, Liu L, Tripathi PV, Steeper KM, Rando TA (2012) Notch signaling is necessary to maintain quiescence in adult muscle stem cells. Stem Cells, 30: 232-242.

Charville GW, Rando TA (2011) Stem cell aging and non-random chromosome segregation. Proc Roy Soc London, 366: 85-93.

Boutet SC, Biressi S, Iori K, Natu V, Rando TA (2010) Taf1 regulates Pax3 protein by monoubiquitination in skeletal muscle progenitors. Molecular Cell, 40: 749-761.

Biressi S, Rando TA (2010) Heterogeneity of muscle stem and progenitors in developmental and postnatal myogenesis. Semin Cell Devel Biol, 21: 845-854.

Quach NL, Biressi S, Reichardt LF, Keller C, Rando TA (2009) Focal adhesion kinase signaling regulates the expression of caveolin 3 and beta1 integrin, genes essential for normal myoblast fusion. Mol Biol Cell, 20: 3422-3435.

Brack AS, Conboy IM, Conboy MJ, Shen J, Rando TA (2008) A temporal switch from Notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis. Cell Stem Cell, 2: 50-59.

Rando TA (2008) Getting personal with gene therapy for muscular dystrophy. Lancet Neurology, 7: 196-198.

Boutet SC, Disatnik M-H, Chan LS, Iori K, Rando TA (2007) Regulation of Pax3 by proteasomal degradation of mono-ubiquitinated protein in skeletal muscle progenitors. Cell, 130: 349-362.

Rando TA (2007) The immortal strand hypothesis: Segregation and reconstruction. Cell, 129: 1239-1243.

Conboy MJ, Karasov AO, Rando TA (2007) High incidence of non-random template strand segregation and asymmetric fate determination in dividing stem cells and their progeny. PLoS Biology, 5: 1120-1126.

Brack AS, Conboy MJ, Lee M, Roy S, Kuo CJ, Keller C, Rando TA (2007) Increased Wnt signaling during aging alters myogenic stem cell fate and increases fibrosis. Science, 317: 807-810.

Brunet A, Rando TA (2007) Stem to stern. Nature, 449: 288-291.

Dhawan J, Rando TA (2005) Stem cells in postnatal myogenesis: Molecular mechanisms of satellite cell quiescence, activation, and replenishment. Trends Cell Biol, 15: 666-673.

Luo D, Renault VM, Rando TA (2005) The regulation of Notch signaling in muscle stem cell activation and postnatal myogenesis. Semin Cell Devel Biol, 16: 612-622.

Rando TA (2005) The adult muscle stem cell comes of age. Nat Med, 11: 829-831.

Conboy IM, Conboy MJ, Wagers AJ, Girma E, Weissman IL, Rando TA (2005) Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature, 433: 760-764.

Sherwood RI, Christensen JL, Conboy IM, Conboy MJ, Rando TA, Weissman IL, Wagers AJ (2004) Isolation of adult mouse myogenic progenitors: Functional heterogeneity of cells within and engrafting skeletal muscle. Cell, 119: 543-554.

Rando TA (2004) Artificial sweeteners: Enhancing glycosylation to treat muscular dystrophies. New Eng J Med, 351: 1254-1256.