SELECTED PUBLICATIONS

de Morrée A, van Velthoven CTJ, Gan Q, Salvi JS, Klein JDD, Akimenko I, Quarta M, Biressi S, Rando TA (2017) Staufen1 inhibits MyoD translation to actively maintain muscle stem cell quiescence. Proc Natil Acad Sci USA, 114(43):E8966-E9005.

van Velthoven CTJ, de Morree A, Egner IM, Brett JO, Rando TA (2017) Transcriptional Profiling of Quiescent Muscle Stem Cells In Vivo. Cell Rep, 21(7),1994-2004.

Tang H, L Kennedy C, Lee M, Gao Y, Xia H, Olguin F, Fraga DA, Ayers K, Choi S, Kim M, Tehrani A, Sowb YA, Rando TA, Shrager JB (2017) Smad3 initiates oxidative stress and proteolysis that underlies diaphragm dysfunction during mechanical ventilation. Sci Rep, 7(1):14530.

Haller S, Kapuria S, Riley RR, O’Leary MN, Schreiber KH, Andersen JK, Melov S, Que J, Rando TA, Rock J, Kennedy BK, Rodgers JT, Jasper H (2017) mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance. Cell Stem Cell, 21(6):806-818.

Rando TA, Ambrosio F (2018) Regenerative Rehabilitation: Applied Biophysics Meets Stem Cell Therapeutics. Cell Stem Cell, 22(3):306-309.

Judson RN, Quarta M, Oudhoff MJ, Soliman H, Yi L, Chang CK, Loi G, Vander Werff R, Cait A, Hamer M, Blonigan J, Paine P, Doan LTN, Groppa E, He W, Su L, Zhang RH, Xu P, Eisner C, Low M, Barta I, Lewis CB, Zaph C, Karimi MM, Rando TA, Rossi FM (2018) Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential. Cell Stem Cell, 22(2):177-190.

Leeman DS, Hebestreit K, Ruetz T, Webb AE, McKay A, Pollina EA, Dulken BW, Zhao X, Yeo RW, Ho TT, Mahmoudi S, Devarajan K, Passegué E, Rando TA, Frydman J, Brunet A (2018) Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging. Science, 359(6381):1277-1283.

Wosczyna MN, Rando TA (2018) A Muscle Stem Cell Support Group: Coordinated Cellular Responses in Muscle Regeneration. Dev Cell, 46(2):135-143.

Filareto A, Maguire-Nguyen K, Gan Q, Aldanondo G, Machado L, Chamberlain JS, Rando TA (2018) Monitoring disease activity noninvasively in the mdx model of Duchenne muscular dystrophy. Proc Natl Acad Sci USA, 115(30):7741-7746.

Liu L, Charville GW, Cheung TH, Yoo B, Santos PJ, Schroeder M, Rando TA (2018) Impaired Notch Signaling Leads to a Decrease in p53 Activity and Mitotic Catastrophe in Aged Muscle Stem Cells. Cell Stem Cell, 23(4):544-556.e4.

van Velthoven CTJ, Rando TA (2019) Stem Cell Quiescence: Dynamism, Restraint, and Cellular Idling. Cell Stem Cell, 24(2):213-225.

Quarta M, Cromie M, Chacon R, Blonigan J, Garcia V, Akimenko I, Hamer M, Paine P, Stok M, Shrager JB, Rando TA (2017) Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss. Nature Commun, 8.

Stearns‐Reider KM, D’Amore A, Beezhold K, Rothrauff B, Cavalli L, Wagner WR, Vorp DA, Tsamis A, Shinde S, Zhang C, Barchowsky A, Rando TA, Tuan RS, Ambrosio F (2017) Aging of the skeletal muscle extracellular matrix drives a stem cell fibrogenic conversion. Aging Cell, 16(3), 518-528.

Rodgers, JT, Schroeder, MD, Ma, C,  Rando, TA (2017) HGFA Is an Injury-Regulated Systemic Factor that Induces the Transition of Stem Cells into G Alert. Cell Reports, 19(3), 479-486.

Luo, D, de Morree, A, Boutet, S, Quach, N, Natu, V, Rustagi, A, Rando, TA (2017) Deltex2 represses MyoD expression and inhibits myogenic differentiation by acting as a negative regulator of Jmjd1c. Proceedings of the National Academy of Sciences, 201613592.

Brunet, A, Rando, TA (2017) Interaction between epigenetic and metabolism in aging stem cells. Curr Opin Cell Bio, 45, 1-7.

Mueller, A A, Van Velthoven, C T, Fukumoto, K.D, Cheung, TH,  Rando, T A (2016) Intronic polyadenylation of PDGFRα in resident stem cells attenuates muscle fibrosis. Nature, 540(7632), 276.

Quarta M, Brett JO, DiMarco R, De Morree A, Boutet SC, Chacon R, Gibbons MC, Garcia VA, Su J, Shrager JB, Heilshorn S, Rando, TA (2016) An artificial niche preserves the quiescence of muscle stem cells and enhances their therapeutic efficacy. Nature Biotech, 34(7), 752-759.

Goodell MA, Rando TA (2015) Stem cells and healthy aging. Science, 350: 1199-1204.

Liu L, Cheung TH, Charville GW, Rando TA (2015) Isolation of skeletal muscle stem cells by fluorescence-activated cell sorting. Nat Prot, 10: 1612-1624.

Bursac N, Juhas M, Rando TA (2015) Synergizing Engineering and Biology to Treat and Model Skeletal Muscle Injury and Disease. Annu Rev Biomed Eng, 17: 217-242.

Tang AH, Rando TA (2014) Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation. EMBO J, 33: 2782-2797.

Rodgers JT, King KY, Brett JO, Cromie MJ, Charville GW, Maguire KK, Brunson C, Mastey N, Liu L, Tsai CR, Goodell MA, Rando TA (2014) mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert). Nature, 510: 393-396.

Brett JO, Rando TA. (2014)  Alive and well? Exploring disease by studying lifespan. Curr Opin Genet Dev, 26: 33-40.

Liu L, Cheung TH, Charville GW, Hurgo BM, Leavitt T, Shih J, Brunet A, Rando TA (2013) Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging. Cell Rep, 4: 189-204

Mueller AA, Cheung TH, Rando TA (2013) All’s well that ends well: Alternative polyadenylation and its implications for stem cell biology. Curr Opin Cell Bio, 25: 222-232.

Maguire KK, Lim LE, Speedy S, Rando TA (2013) Assessment of disease progression in muscular dystrophies by non-invasive imaging. J Clin Invest, 123: 2298-2305.

Cheung TH, Rando TA (2013) Molecular regulation of stem cell quiescence. Nat Rev Mol Cell Biol,14: 329-340.

Boutet SC, Cheung TH, Quach NL, Liu L, Prescott SL, Edalati A, Iori K, Rando TA (2012) Alternative polyadenylation mediates microRNA regulation of muscle stem cell function. Cell Stem Cell, 10: 327-336.

Cheung TH, Quach NL, Charville GW, Liu L, Park L, Edalati A, Yoo B, Hoang P, Rando TA (2012) Maintenance of muscle stem-cell quiescence by microRNA-489. Nature, 482: 524-528.

Rando TA, Chang HY (2012) Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock. Cell, 148: 46-57.