The International Society for Stem Cell Research (ISSCR) will award its 2023 ISSCR Achievement Award to Thomas A. Rando, M.D., Ph.D., director of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and professor of Neurology and of Molecular, Cell, and Developmental Biology, UCLA, USA. The prize recognizes the transformative body of work of an investigator that has had a major impact on the field of stem cell research or regenerative medicine. He will present his research on 17 June 2023 during Plenary VII at ISSCR 2023 Boston + Virtual, the world’s leading gathering of the brightest minds in stem cell research and regenerative medicine.
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Recognizing their outstanding contributions to the advancement of science and human progress through their pioneering, innovative and collaborative research, the 2022 NOMIS Distinguished Scientist and Scholar Award was presented to Magdalena Zernicka-Goetz of the California Institute of Technology (Caltech) and the University of Cambridge and to Thomas A. Rando of the University of California, Los Angeles (UCLA) at a ceremony held at the Kongresshaus Zurich on Oct. 6, 2022.
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We’ve all met older adults who seem younger, whose bodies and brains seem decades nimbler than their actual ages, and wondered, “What makes them different?” Despite the wide range of supplements and related products that claim, without scientific evidence, that they can turn back the years, the key to foiling Father Time may lie in the field of epigenetics. Documents for a married couple – in 95% of cases, spouses applying for a mortgage become co-borrowers and are equally responsible for repaying the loan. Borrowers in a registered relationship must provide the same package of documents as the marriage certificate. When calculating the loan, the total family income will be taken into account, so a married couple can count on more favorable take control of your finances conditions. In the case of a co-borrower / guarantor, the parties to the transaction bear the same financial responsibility as the borrower, therefore, no less strict requirements are imposed on them. In addition to the standard list of documents for a mortgage, at the request of the bank, the guarantor is obliged to provide a tax return for the last year, a photocopy of the employment contract and a certificate in the form of 2-NDFL. … The co-borrower must, among other things, provide a pension insurance certificate.
http://randolab.stanford.edu/wp-content/uploads/2017/10/Rando-Lab-Logo-01-450x204.png00dpaganohttp://randolab.stanford.edu/wp-content/uploads/2017/10/Rando-Lab-Logo-01-450x204.pngdpagano2021-03-26 17:02:422021-05-06 17:09:57NIA: The Epigenetics of Aging: What the Body’s Hands of Time Tell Us
Aging is the result of the deterioration of cells. By reprogramming cells to an embryonic state, we can effectively reverse aging affects in human cells. This scientist wants to cure aging, which would eliminate arthritis, osteoporosis, and other diseases that appear later in life. Listen
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The researchers also identified a molecular pathway involved in turning back the clock on the cells. Drugs that could manipulate the pathway might be an effective substitute for exercise, they suggest.
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Pretreatment with a stem-cell-activating protein significantly enhances healing in mice, Stanford researchers say. The approach could eventually help people going into surgery or combat heal better from injuries they sustain.
Is it real or science fiction to dream of being able to treat… getting old? In this episode, we discuss with Dr. Thomas Rando from Stanford, Kristen Fortney, CEO of BioAge, and a16z’s general partner Vijay Pande where we are in the field of “geroscience” — the idea of studying aging itself, and aging as the root risk for all aging related disease. Far from science fiction, recent discoveries have given us a whole crop of promising breakthroughs to treat aging, such as parabiosis (young blood infused into old blood), senolytics, and rapamycin, and more.
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At the Salk Institute in La Jolla, Calif., scientists are trying to get time to run backward. Biological time, that is. In the first attempt to reverse aging by reprogramming the genome, they have rejuvenated the organs of mice and lengthened their life spans by 30 percent. The technique, which requires genetic engineering, cannot be applied directly to people, but the achievement points toward better understanding of human aging and the possibility of rejuvenating human tissues by other means.
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The National Academy of Medicine announced today the election of 70 regular members and 9 international members during its annual meeting. Election to the Academy is considered one of the highest honors in the fields of health and medicine and recognizes individuals who have demonstrated outstanding professional achievement and commitment to service. Dr. Thomas Rando was among those elected.
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Stem cells typically lose the capacity to differentiate when cultured in vitro. Their potency appears to depend on preserving the quiescent state, which has been difficult to accomplish with traditional culture methods. In the body, stem cells reside in specialized microenvironments, or niches, with unique chemical and physical properties. Quiescent stem cells isolated from their native environment and then plated become activated to divide and differentiate. A Stanford University research group led by Dr. Thomas A. Rando sought to create an enhanced culture system for studying the biology of quiescence.
But in the harsh reality of normal girls, witnessing such a street incident, resolutely speed up the pace, looking straight ahead. I don’t recommend it. From the bottom of my heart I do not recommend it. No, no, this does not mean liveescorts begging for money, cigarettes, and a phone for a second – call my mom. This is beyond good and evil. A lighter is much better.
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We are often told that sleep is one of the most important elements of a healthy lifestyle, that it helps in the healing and repair of our heart and blood vessels – among other things.
It turns out that sleep, or something very similar, is equally important for stem cells, helping them retain their power or potency, which is a measure of their effectiveness and efficiency in generating the mature adult cells that are needed to repair damage. Now researchers from Stanford, with a little help from CIRM, have found a way to help stem cells get the necessary rest before kicking in to action. This could pave the way for a whole new approach to treating a variety of genetic disorders such as muscular dystrophy.
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There’s no place like home — particularly if you’re a muscle stem cell.
Snuggled comfortably along the length of our muscle fibers, these stem cells rest quietly, biding their time until the muscle needs to be repaired after injury. Although it’s possible to maintain muscle stem cells in a laboratory dish, they’re not really happy there. Within a short time they begin to divide and lose their ability to function as stem cells.
Now researchers at the Stanford University School of Medicine have come up with a way to create a home away from home for the stem cells in the form of artificial muscle fibers. They’ve also identified the particular “soup” of molecules and nutrients necessary to keep the cells in their most potent, regenerative state.
“Normally these stem cells like to cuddle right up against their native muscle fibers,” said Thomas Rando, MD, PhD, professor of neurology. “When we disrupt that interaction, the cells are activated and begin to divide and become less stemlike. But now we’ve designed an artificial substrate that, to the cells, looks, smells and feels like a real muscle fiber. When we also bathe these fibers in the appropriate factors, we find that the stem cells maintain high-potency and regenerative capacity.”
Dr. Rando participated in a webinar hosted by the journal ‘Current Opinion in Cell Biology’, and sponsored by Beckman Coulter. A recording is available on demand at the link to the left.
Many adult stem cells reside in the quiescent state, or the G0 state of the cell cycle, for prolonged periods of time. This state, one reversible cell cycle withdrawal, has long been viewed as a dormant state with minimal basal activity. However, increasingly there is evidence that suggests that quiescent cells have specific transcriptional, post-transcriptional and metabolic programs that serve at least two functions. The first is to actively maintain the quiescent state, indicating that this is not simply a state of dormancy but in fact under active regulation. The second is to prime the cells for activation, a process that is characterized by the upregulation of multiple cellular processes necessary for cells to enter the cell cycle and begin the process of differentiation.
Skeletal muscle stem cells, or satellite cells, have proven to be extremely valuable in the study of stem cell quiescence because they persist in the quiescent state for weeks, months, and at least in long-lived mammals, perhaps years. In addition, they can be readily identified in situ, they can be rapidly purified by FACS at very high yield and very high purity, and the states of quiescence, activation and “re-quiescence” (i.e. the process by which a proliferating cell returns to quiescence in the process of stem cell self-renewal) can be modeled and studied in vitro. We have focused our studies of stem cell quiescence on this population, and we have discovered unexpected levels of regulation of quiescence and activation. These include the maintenance of the quiescent state by quiescence-specific miRNAs and by active signaling via the Notch pathway. Recent epigenetic profiling using ChIP-seq analysis has revealed evidence of dynamic regulation of chromatin in quiescent stem cells and intriguing epigenetic changes that occur during chronological stem cell aging. Finally, recent results from our laboratory have revealed an unexpected ability of quiescent stem cells to respond to systemic signals and poise themselves in a “pre-activation” state, which we call the “alert state”, and which suggests that in addition to the traditional cell cycle there is also a “quiescence cycle” that allows stem cells to cycle between the quiescent state and the alert state while remaining in G0. Deciphering the molecular mechanisms regulating the quiescent state of adult stem cells will offer new insights into how tissue regeneration is accomplished and how it is dys regulated in pathological conditions and in ageing.
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Dr. Rando and his co-principal investigator, Tony Wyss-Coray, PhD, were awarded one of 10 Transformative Research by the NIH. These awards, open to both individuals and teams of investigators, were created to support research projects that have the potential to create or overturn fundamental paradigms.
“Thomas Rando, MD, PhD, professor of neurology, and Tony Wyss-Coray, PhD, professor of neurology and a senior research career scientist at the Veterans Affairs Palo Alto Health Care System, have received a $4.26 million award to explore the basis for physical activity’s robust positive effect on cognitive function.
Aging is associated with a progressive decline in cognitive ability, the consequences of which can be enormous for individuals and society. Muscle is increasingly understood to be a secretory tissue with effects on bone structure, metabolism and blood vessel formation.
Using innovative experimental models and tools, the Rando and Wyss-Coray teams will test the idea that factors produced in exercised muscle are secreted into the circulation, where they gain access to the brain and induce cognitive benefits. In particular, the researchers will investigate the mechanisms by which the profile of factors secreted by muscle tissue changes during exercise.
Further, they will identify the neural cells whose behavior is modified by those secreted factors and that mediate the effects those factors induce during exercise, as well as afterward. The results of these endeavors may drastically alter current thinking about exercise’s beneficial effects on the brain cells’ function and regeneration, remodeling of neuronal circuitry, and cognition itself.
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A chemical code scrawled on histones — the protein husks that coat DNA in every animal or plant cell — determines which genes in that cell are turned on and which are turned off. Now, Stanford University School of Medicine researchers have taken a new step in the deciphering of that histone code.
In a study published June 27 in Cell Reports, a team led by Thomas Rando, MD, PhD, professor of neurology and neurological sciences and chief of the Veterans Affairs Palo Alto Health Care System’s neurology service, has identified characteristic differences in “histone signatures” between stem cells from the muscles of young mice and old mice. The team also distinguished histone-signature differences between quiescent and active stem cells in the muscles of young mice.
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Thomas Rando, M.D., Ph.D., professor of neurology and neurological sciences at Stanford University School of Medicine and director of Stanford’s Glenn Laboratories for the Biology of Aging, has focused his entire career researching muscular dystrophy.
The main areas of interest of the Rando Laboratory are muscle stem cell biology, muscle stem cell aging, muscular dystrophies, tissue engineering and basic muscle cell biology. Dr. Rando’s research focuses on the restorative and repair mechanism of stem cells. The lab has a long-standing interest in understanding the mechanisms of cell injury and cell death in muscular dystrophies and the development of novel therapeutics. The long term goal is to develop stem cell therapies for Duchenne muscular dystrophy.
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